Invitro ADME Scientist at Syngene! MSc Biological Sciences Apply Now
Title: Invitro ADME Scientist
Date: 4 Nov 2024
Job Location: Hyderabad
Pay Grade: 8-II
Year of Experience: 9 – 12 Years
Designation: Invitro ADME Scientist
Job Location: Bangalore/Hyderabad
Department: Discovery Biology
About Syngene
Syngene (www.syngeneintl.com) is an innovation-led contract research, development, and manufacturing organization offering integrated scientific services from early discovery to commercial supply.
At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit.
Mandatory expectation for all roles as per Syngene safety guidelines
- Overall adherence to safe practices and procedures for oneself and aligned teams.
- Contributing to the development of procedures, practices, and systems that ensure safe operations and compliance with the company’s integrity & quality standards.
- Driving a corporate culture that promotes an environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
- Ensuring safety of self, teams, and lab/plant by adhering to safety protocols and following EHS requirements in the workplace.
- Completing all assigned mandatory training related to data integrity, health, and safety measures on time for all team members, including self.
- Compliance with Syngene’s quality standards at all times.
- Holding self and teams accountable for achieving safety goals.
- Governing and reviewing safety metrics from time to time.
Job Purpose
- Support the ADME team by planning and conducting metabolic stability, single-point inhibition, reversible CYPIC50 inhibition, and TDI-IC50 shift assays using human liver microsomes with high quality.
- Support Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, and MDCK-II BCRP transporter assays in 24 well/96 well plate trans-well assays using different matrices with high quality.
- Design and execute physio-chemical and protein binding assays, generate high-quality data, review, and upload data into databases with additional QC checks.
- Manage time and multitasking to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
- Record lab activities and experiments contemporaneously, maintain high housekeeping standards.
- Adhere to all safety rules and maintain a safe workplace.
- This role is predominantly laboratory-based.
Key Responsibilities:
- Extensive experience in planning metabolic stability, CYP inhibition assays, cell culture activities, and metabolism studies.
- Design and execute in-vitro single-point inhibition, reversible CYPIC50 inhibition, and TDI-IC50 shift assay with human liver microsomes.
- Coordinate seamlessly with the BA-DMPK group to design in-vitro CYP inhibition studies.
- Prepare SOPs and EOPs.
- Report executed studies without noncompliance.
- Present study results clearly in cross-functional scientific meetings.
- Follow EHS requirements at all times, ensuring individual and lab/plant safety.
- Ensure EHS measures are imparted via training and adhered to within the team.
Educational Qualification:
- M. Pharm. in pharmaceutical sciences or M.Sc. in biological science.
Technical/Functional Skills:
- Comprehensive understanding of in vitro ADME assays with technical expertise in troubleshooting assays.
- In-depth understanding of biochemical aspects of enzyme kinetics related to metabolism.
- Proficiency in software such as Microsoft Excel and GraphPad Prism.
- Demonstrated cross-functional leadership capabilities.
- Experience with automation is desirable.
Experience:
- M. Pharm. in pharmaceutical sciences or M.Sc. in biological science with nine or more years of industrial experience in DMPK/ADME research.
Behavioral Skills:
- Demonstrate the ability to be a team player.
- Commitment to deliver study reports within the agreed timelines.
- Adaptability to changes in a dynamic lab environment.
- Confident communication with colleagues and collaborators in meetings and presentation of study reports.
- Evidence of publications in peer-reviewed journals.
Apply Link: Apply Now
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