Bioinformatics Associate Scientist at Syngene – Apply Now!
Title: Associate Scientist
Date: 28 Aug 2024
Job Location: Bangalore
Pay Grade: 8-I
Year of Experience: 5 – 7 Years
JOB DESCRIPTION
Designation: Senior/Associate Scientist
Job Location: Bangalore
Department: Informatics and Predictive Sciences (BBRC-IPS)
About Syngene
Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development, and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical industries around the world. Syngene’s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA, and Herbalife. Its innovative culture is driven by the passion of its 4240-strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market, and lower the cost of innovation.
Job Purpose
We are seeking innovative scientists for a Research Scientist / Senior Research Scientist position to join our Informatics and Predictive Sciences (BBRC-IPS) group that is part of the main Discovery Biology and Translational Sciences (DBTS) team. The group works on real-world health data, designs experiments, and analyzes both pre-clinical and clinical -omics data sets, including Exome, Whole Genome Sequencing, RNA-Seq, single-cell sequencing
, high-throughput proteomics, multiplex flow cytometry, CRISPR, etc., to nominate novel drug targets, enable patient enrichment strategies, and guide drug development decisions. You will be responsible for developing, implementing, and maintaining computational pipelines to analyze this data and generate meaningful biological insights.Key Responsibilities:
- Identify and implement state-of-the-art statistical methods for data exploration, visualization, analysis, and integration of cancer genomics/epi-genomics, and other forms of high-dimensional -omics data for patient clinical outcomes
- Develop and implement computational pipelines using Python, R, Bash, and AWS to analyze NGS data (WES, WGS, MRD, ctDNA, CRISPR) for tasks like tumor load distribution, MRD status, immune cell analysis, and variant calling
- Evaluate the performance of NGS assays (sensitivity, accuracy, concordance)
- Utilize machine learning and statistical analysis to identify clinically relevant insights from NGS data, including associations between gene expression, IHC markers, immune cell populations, and clinical outcomes
- Develop and evaluate the performance of existing or new assays through statistical inferences
- Interpret quality control data metrics in NGS methodology and communicate effectively with the team and respective stakeholders
- Collaborate closely with others on translational research teams to evaluate, develop, and apply cutting-edge methods for the analysis of multi-modal, high-dimensional -omics data
Educational Qualification:
Master’s degree in Biotechnology, Bioinformatics, Biostatistics, Computer Science, or a related field
Experience:
- 3+ years of experience in a pharma/biotech research environment preferable
- 3+ years of experience in university, hospital, or biotechnology environments
Technical/Functional Skills
- Expertise in algorithmic implementation, statistical programming, and data manipulation, using e.g., R or Python, and contemporary, open-source bioinformatics tools and database structures
- Solid grounding in statistical theory and familiarity with recent developments in statistics
- Skilled at working with large omics data sets (transcriptomic, genomic, proteomic, and/or epigenomic data)
- Understanding of cancer genomics and epi-genomics is required
- Proficient with high-performance computing environments like cloud computing (AWS)
- Working knowledge of workflow languages such as CWL or Nextflow
- Working knowledge of web frameworks like R Shiny or Django
Behavioral Skills:
- Strong problem-solving and collaboration skills, and rigorous and creative thinking
- Excellent written and oral communication skills, including an ability to discuss and explain complex ideas with computational scientists, experimentalists, and clinicians
- The ability to work across organizations to define and solve problems that will benefit the whole. Capable of establishing strong working relationships across the organization.
- Enjoy collaborating to solve challenging problems at the intersection of modern statistics and medicine to help bring new medicines to patients
Keywords: Associate Scientist, Syngene, Bangalore, Bioinformatics, Biotechnology. Bioinformatics Associate Scientist at Syngene – Apply Now! Please ensure you are subscribed to the Biotecnika Times Newsletter and our YouTube channel to be notified of the latest industry news. Follow us on social media like Twitter, Telegram, Facebook
