yle="text-align: center;">MAHE JRF Recruitment For MSc/MTech Biotech, Life Sciences, Biochem, Mol Bio, Applications Invited
MAHE JRF Recruitment For MSc/MTech Biotech, Life Sciences, Biochem, Mol Bio, Applications Invited. MSc Biotechnology / Biochemistry/ Microbiology/Molecular Biology / Life Science, MTech Biotechnology Junior Research Fellow Job opening. Interested and eligible applicants can check out all of the details on the same below
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Junior Research Fellow
Manipal Academy of Higher Education (MAHE), Manipal invites applications for the position of Junior Research Fellow for the ICMR funded project titled “Development of three dimensional in vitro bioprinted liver disease model for anti fibrotic drug(s) screening” at the Manipal Centre for Biotherapeutics Research (MCBR), MAHE, Manipal.
Post name: Junior Research Fellow
No. of Posts: 01
Job code: ‘ICMR-JRF at MCBR, MAHE, Manipal’ – Mentioning of Job Code in the subject line of the application is mandatory.
Name of the Project: “Development of three dimensional in vitro bioprinted liver disease model for anti fibrotic drug(s) screening”.
Duration of the Post: 15 months
How to apply:
Candidates possessing the requisite qualification may send their detailed CVs on or before July 7, 2023 to the following address. Shortlisted candidates will be informed by e-mail about the interview date. No TA/DA will be paid for attending the interview.
Director – HR
Manipal Academy of Higher Education
Madhav Nagar, Manipal 576104
Udupi, Karnataka, India
e-mail: [email protected] | Phone: 0820 -2923433
Remuneration: Rs.31,000/- + 9% HRA/month
Essential Qualification:
- M.Sc (Biotechnology / Biomedical / Biochemistry/ Microbiology/Molecular Biology / Biomedical Science / Life Science)
- M.Tech (Biotechnology /Biomedical Engineering)
- M.Pharm with First Class
- Experience in In vitro culture and molecular biology techniques along with animal handling will be preferred.
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Here are a few interview questions with answers for the position of Junior research fellow at Manipal.
1. Can you tell us about your experience with in vitro culture techniques and molecular biology?
Answer: Yes, I have gained extensive experience in in-vitro culture techniques and molecular biology during my academic and research journey. I have successfully conducted cell culture experiments, including maintaining cell lines, culturing primary cells, and optimizing culture conditions. Additionally, I have hands-on experience with molecular biology techniques such as DNA and RNA extraction, PCR, gel electrophoresis, and gene expression analysis. I have also been involved in designing and executing experiments to study cellular responses and molecular mechanisms in various research projects.
2. How comfortable are you with animal handling, and why is it important for this research project?
Answer: I am comfortable with animal handling and have previous experience working with laboratory animals. I understand the importance of proper animal handling techniques to ensure the welfare of the animals and the reliability of experimental results. In this research project, animal handling is crucial as it allows us to validate the findings from the in vitro bioprinted liver disease model. Animal studies provide an opportunity to observe the effects of anti-fibrotic drugs in vivo, understand their pharmacokinetics, and assess their overall efficacy before moving towards clinical trials. I am committed to following ethical guidelines and maintaining high standards of animal welfare throughout the study.
3. What specific skills or expertise do you bring that would be valuable for the development of a three-dimensional in vitro bioprinted liver disease model?
Answer: I possess several skills and expertise that would be valuable for developing a three-dimensional in vitro bioprinted liver disease model. Firstly, I have a strong background in biotechnology and biomedical sciences, which provides me with a solid understanding of the principles and techniques involved in tissue engineering and bioprinting. Secondly, I have hands-on experience with cell culture and tissue engineering techniques, including scaffold fabrication, cell seeding, and culture optimization. Additionally, my knowledge of molecular biology enables me to analyze gene expression patterns and evaluate the functionality of the bioprinted liver disease model. Overall, my interdisciplinary expertise makes me well-suited for contributing to the development of this innovative model.
4. How would you approach the screening of anti-fibrotic drugs using the three-dimensional in vitro bioprinted liver disease model?
Answer: To screen anti-fibrotic drugs using the three-dimensional in vitro bioprinted liver disease model, I would follow a systematic approach. Firstly, I would optimize the bioprinting process to ensure the creation of a reliable and reproducible liver disease model. This would involve selecting appropriate bioinks, optimizing cell densities, and establishing culture conditions that mimic the fibrotic microenvironment. Once the model is established, I would systematically evaluate the effects of different anti-fibrotic drugs by treating the bioprinted liver tissues with varying concentrations of these drugs. I would assess the drug’s impact on key fibrotic markers, such as collagen deposition and fibrotic gene expression. Furthermore, I would utilize imaging techniques, such as confocal microscopy, to visualize the structural changes in the bioprinted tissues after drug treatment. Overall, my approach would involve a combination of molecular and imaging analyses to identify promising anti-fibrotic candidates for further validation and potential translation into clinical applications.
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