COVID19 Detected Within 10 Minutes – New COVID-19 Diagnostic Test
An experimental COVID-19 diagnostic test that can visually detect the presence of coronavirus in 10 minutes has been developed by a team of US scientists led by an Indian-origin researcher.
The test uses a simple assay containing plasmonic gold nanoparticles to detect a color change when the virus is present and was developed by the University of Maryland School of Medicine scientists.
Techniques used commonly for amplifying DNA, and other advanced laboratory techniques for analysis are not required in this test.
A professor of diagnostic radiology and nuclear medicine and pediatrics, the study leader Dipanjan Pan said, “We believe this promising new test may detect RNA material from the virus as early as the first day of infection based on our preliminary results. However, to confirm whether this is indeed the case, additional studies are needed.”
Via a simple process that takes about 10 minutes, the RNA is extracted from the nasal swab or saliva sample obtained from a patient.
To detect a particular protein, a highly specific molecule attached to the gold nanoparticles is used in the test. This protein is part of the SARS-CoV-2 virus’ genetic sequence.
The
liquid reagent is turned from purple to blue as a response of gold nanoparticles when the biosensor binds to the virus’s gene sequence.Dr. Pan informed that “A test being able to reliably detect any virus shows the accuracy of any COVID-19 test. Thus, if the virus is not present in the sample, such a test will not give a false-positive result, nor a false negative result if there is an actual presence of the virus actually.”
The virus cannot be detected until several days of infection by many of the diagnostic tests on the market currently. An increased rate of false-negative results is seen due to this reason.
To discuss requirements for getting an emergency use authorization for the test, within the next two months, Dr. Pan now plans to have a pre-submission meeting with the US Food and Drug Administration (FDA).
Matthew Frieman, the study’s co-author, “In terms of detecting the virus, this RNA-based test appears to be very promising.”
Dr. Pan’s team included research fellow Maha Alafeef, Parikshit Moitra, along with research fellow from the University of Maryland, Baltimore County, Ketan Dighe.
In the ACS Nano (American Chemical Society’s nanotechnology) journal, the authors published their work.
Source
COVID19 Detected Within 10 Minutes
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Hope you do best at your end.