A Step closer to HIV Cure reality | Scientists successfully remove Virus DNA from living tissue
A breakthrough in HIV Cure. Researchers from the Temple University have managed to remove the HIV virus DNA from living tissue for the first time. And this could lead to an outright cure.
At present, the only way of treating the disease is the use of drugs that suppress levels of the virus so the body’s immune system can cope.
But now researchers in the US have revealed that they used gene-editing technology to remove DNA of the commonest HIV-1 strain from several organs of infected mice and rats.
During the past month, the same team reported that they had successfully eliminated the virus from human cells in the laboratory, but the study revealed they had managed to do the same thing in live animals for the first time.
The researchers’ team leader, Professor Kamel Khalili, of Temple University, said: “In a proof-of-concept study, we showed that our gene-editing technology can be effectively delivered to many organs of two small animal models and excise large fragments of viral DNA from the host cell genome.”
The current antiretroviral drugs for HIV are not able to eliminate HIV-1 from the infected cells.
And if treatment is interrupted, the virus can start replicating quickly, putting patients of risk of getting full-blow AIDS.
This is because it is able to persist in immune system T-cells and other places where it is not actually active and is unaffected by the current treatments.
The researchers used a specially adapted virus to deliver the gene-editing system into the cells.
“The ability of the rAAV delivery system to enter many organs containing the HIV-1 genome and edit the viral DNA is an important indication that this strategy can also overcome viral reactivation from latently infected cells and potentially serve as a curative approach for patients with HIV,” Professor Khalili said.
In a statement, Temple University said the implications of the new study were “far-reaching”.
“The gene-editing platform by itself may be able to eradicate HIV-1 DNA from patients, but it is also highly flexible and potentially could be used in combination with existing antiretroviral drugs to further suppress viral RNA. It also could be adapted to target mutated strains of HIV-1,” it added.
Professor Khalili said a clinical trial could happen within the next few years, but he first planned to carry out a similar study involving a larger group of animals.
